The Cardiovascular Research Group is studying
how the heart generates and maintains its regular
beat, and controls its force of contraction.
Accili is studying proteins that enable the
heart to initiate its own rhythm independently of
the nervous system.
and Steven Kehl
are studying how the heart generates,
maintains and regulates electrical activity. Electrical
potential is transmitted across the heart as the
cells alternately depolarize and re-polarize, due
to the coordinated action of a multitude of intramembrane
proteins. Any defects in this action can trigger
atrial fibrillation and a variety of ventricular
Harley Kurata studies regulatory mechanisms of
inwardly-rectifying potassium (Kir) channels. Current research is aimed towards identifying
novel interactors and regulators of channel function, and investigating the detailed mechanisms of
Kir channel gating and blockade.
Moore is studying the mechanisms which control
excitation-contraction coupling in muscle cells.
Petegem is investigating the structure and function
of calcium channels and ryanodine receptors using
protein crystallography as well as electrophysiological
and biochemical techniques
We are located in the new Life
Sciences Institute at the University
of British Columbia, Vancouver,
Canada. The LSI, as well as other groups on and
off the UBC campus, includes investigators in a
variety of areas in the Life Sciences. The environment
is stimulating and diverse, and there is access
to excellent core facilities and support. We maintain
collaborations with investigators in Vancouver,
the rest of Canada, the United States and Europe.