Probing the molecular basis of hERG drug block with unnatural amino acids.
Macdonald LC, Kim RY, Kurata HT, Fedida D.
Sci Rep. 2018 Jan 10;8(1):289. doi: 10.1038/s41598-017-18448-x.
Hou P, Eldstrom J, Shi J, Zhong L, McFarland K, Gao Y, Fedida D, Cui J.
Nat Commun. 2017 Nov 23;8(1):1730. doi: 10.1038/s41467-017-01911-8.
The Fast Component of hERG Gating Charge: An Interaction between D411 in the S1 and S4 Residues.
Dou Y, Macdonald LC, Wu Y, Fedida D.
Biophys J. 2017 Nov 7;113(9):1979-1991. doi: 10.1016/j.bpj.2017.09.004.
Photo-Cross-Linking of IKs Demonstrates State-Dependent Interactions between KCNE1 and KCNQ1.
Westhoff M, Murray CI, Eldstrom J, Fedida D.
Biophys J. 2017 Jul 25;113(2):415-425. doi: 10.1016/j.bpj.2017.06.005.
cAMP-dependent regulation of IKs single-channel kinetics.
Thompson E, Eldstrom J, Westhoff M, McAfee D, Balse E, Fedida D.
J Gen Physiol. 2017 Aug 7;149(8):781-798. doi: 10.1085/jgp.201611734. Epub 2017 Jul 7.
Binding and Proton Blockage by Amantadine Variants of the Influenza M2WT and M2S31N Explained.
Tzitzoglaki C, Wright A, Freudenberger K, Hoffmann A, Tietjen I, Stylianakis I, Kolarov F, Fedida D, Schmidtke M, Gauglitz G, Cross TA, Kolocouris A.
J Med Chem. 2017 Mar 9;60(5):1716-1733. doi: 10.1021/acs.jmedchem.6b01115. Epub 2017 Feb 15.
Bround MJ, Wambolt R, Cen H, Asghari P, Albu RF, Han J, McAfee D, Pourrier M, Scott NE, Bohunek L, Kulpa JE, Chen SR, Fedida D, Brownsey RW, Borchers CH, Foster LJ, Mayor T, Moore ED, Allard MF, Johnson JD.
J Biol Chem. 2016 Nov 4;291(45):23490-23505. Epub 2016 Sep 12.
Novel Acylguanidine-Based Inhibitor of HIV-1.
Mwimanzi P, Tietjen I, Miller SC, Shahid A, Cobarrubias K, Kinloch NN, Baraki B, Richard J, Finzi A, Fedida D, Brumme ZL, Brockman MA.
J Virol. 2016 Sep 29;90(20):9495-508. doi: 10.1128/JVI.01107-16. Print 2016 Oct 15.
hERG long QT syndrome type 2 mutants need more than a chaperone to dance.
Fedida D, Macdonald L.
J Physiol. 2016 Aug 1;594(15):4095-6. doi: 10.1113/JP272417. No abstract available.
Tietjen I, Gatonye T, Ngwenya BN, Namushe A, Simonambanga S, Muzila M, Mwimanzi P, Xiao J, Fedida D, Brumme ZL, Brockman MA, Andrae-Marobela K.
J Ethnopharmacol. 2016 Sep 15;191:331-340. doi: 10.1016/j.jep.2016.06.040. Epub 2016 Jun 24.
Jalily PH, Eldstrom J, Miller SC, Kwan DC, Tai SS, Chou D, Niikura M, Tietjen I, Fedida D.
Mol Pharmacol. 2016 Aug;90(2):80-95. doi: 10.1124/mol.115.102731. Epub 2016 May 18.
Moral-Sanz J, Mahmoud AD, Ross FA, Eldstrom J, Fedida D, Hardie DG, Evans AM.
J Physiol. 2016 Sep 1;594(17):4901-15. doi: 10.1113/JP272032. Epub 2016 Jun 30.
Murray CI, Westhoff M, Eldstrom J, Thompson E, Emes R, Fedida D.
Elife. 2016 Jan 23;5. pii: e11815. doi: 10.7554/eLife.11815.
De Novo Mutation in the SCN5A Gene Associated with Brugada Syndrome.
Wang L, Meng X, Yuchi Z, Zhao Z, Xu D, Fedida D, Wang Z, Huang C.
Cell Physiol Biochem. 2015;36(6):2250-62. doi: 10.1159/000430189. Epub 2015 Jul 24.
Tietjen I, Ntie-Kang F, Mwimanzi P, Onguéné PA, Scull MA, Idowu TO, Ogundaini AO, Meva'a LM, Abegaz BM, Rice CM, Andrae-Marobela K, Brockman MA, Brumme ZL, Fedida D.
PLoS One. 2015 Apr 1;10(4):e0121099. doi: 10.1371/journal.pone.0121099. eCollection 2015.
Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways.
Goodchild SJ, Macdonald LC, Fedida D.
Biophys J. 2015 Mar 24;108(6):1435-47. doi: 10.1016/j.bpj.2015.02.014.
Eldstrom J, Wang Z, Werry D, Wong N, Fedida D.
Heart Rhythm. 2014 Oct 29. pii: S1547-5271(14)01246-6. doi: 10.1016/j.hrthm.2014.10.029. [Epub ahead of print]
Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A.
Kolocouris A, Tzitzoglaki C, Johnson FB, Zell R, Wright AK, Cross TA, Tietjen I, Fedida D, Busath DD.
J Med Chem. 2014 Jun 12;57(11):4629-39. doi: 10.1021/jm500598u.
Pourrier M, Williams S, McAfee D, Belardinelli L, Fedida D.
J Physiol. 2014 Feb 1;592(Pt 3):411-4. doi: 10.1113/jphysiol.2013.262261. No abstract available.
Rebuttal from Marc Pourrier, Sarah Williams, Donald McAfee, Luiz Belardinelli and David Fedida.
Pourrier M, Williams S, McAfee D, Belardinelli L, Fedida D.
J Physiol. 2014 Feb 1;592(Pt 3):419. doi: 10.1113/jphysiol.2013.268896. No abstract available.
Ranolazine improves diastolic function in spontaneously hypertensive rats.
Williams S, Pourrier M, McAfee D, Lin S, Fedida D.
Am J Physiol Heart Circ Physiol. 2014 Mar;306(6):H867-81.
Allosteric coupling of the inner activation gate to the outer pore of a potassium channel.
Peters CJ, Fedida D, Accili EA.
Sci Rep. 2013 Oct 23;3:3025. doi: 10.1038/srep03025.
Gating charge movement precedes ionic current activation in hERG channels.
Goodchild SJ, Fedida D.
Channels (Austin). 2014 Jan-Feb;8(1):84-9.
Dou Y, Goodchild SJ, Velde RV, Wu Y, Fedida D.
Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C468-78.
Cheng YM, Fedida D, Kehl SJ.
Pflugers Arch. 2013 Nov;465(11):1545-55
Cytoskeletal Roles in Cardiac Ion Channel Expression.
Steele DF, Fedida D.
Biochim Biophys Acta. 2014 Feb;1838(2):665-73.
Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Baró I, Loussouarn G.
J Biol Chem. 2013 Apr 12;288(15):10951.
Wang Z, Dou Y, Goodchild SJ, Es-Salah-Lamoureux Z, Fedida D.
J Gen Physiol. 2013 Apr;141(4):431-43.
Comment in: The electric heart of hERG. [J Gen Physiol. 2013]
Werry D, Eldstrom J, Wang Z, Fedida D.
Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E996-1005.
Wettwer E, Christ T, Endig S, Rozmaritsa N, Matschke K, Lynch JJ, Pourrier M, Gibson JK, Fedida D, Knaut M, Ravens U.
Cardiovasc Res. 2013 Apr 1;98(1):145-54
Kehl SJ, Fedida D, Wang Z.,
Am J Physiol Cell Physiol. 2013 Feb 15;304(4):C370-81.